Author  
Place of duty  
Title   Expression of Matrix Metalloproteinases and Its Inhibitor in Gastric Adenocarcinoma
Publicationinfo   2001 Jan; 033(03): 199-207.
Key_word   Gastric adenocarcinoma , Matrix metalloproteinases , Tissue inhibitor of metalloproteinase , Invasion , Metastasis
Full-Text  
Abstract   Purpose: Matrix metalloproteinases (MMPs ) have been associated with tumor cell invasion and metas tasis by mediating the degradation of extracellular matrix components. A tissue inhibitor of metallo proteinases (TIMPs ) has been reported to inhibit tumor invasion by means of an inactivation of matrix metalloproteinases . An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignanttumors. The refore, MMPs and their inhibitors constitute promising agents for developing anticancer the rapies. In the present study, the authors investigated the correlation between the express ions of TIMP-1 and MMPs, and the clinical outcome. Materials and Methods: Immunohistochemical staining of MMP-2, -3 and -9, and TIMP-1 was performed on paraffin-e mbedded tissue sections of 38 early gastric carcinomas and 61 advanced gas tric carcinomas. Results: MMP-2 and -9 were found mainly in tumors of the intestinal type and less frequently in those of diffuse type. There were positive correlations between the presence of MMP-2 and -9 and lymph node status. There were inverse correlations between the TIMP-1 expression and tumor invasiveness. Conclusion: These results suggests that clinical outcomes such as the depth of invasion or metastasis are closely related to the expression of TIMP-1, MMP-2 and MMP-9. (Cancer Research and Treatment 2001;33:199 - 206)
저 자   임성철(Sung Chul Lim)